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Grisactin 500 mg ) for 2 to 4 weeks. In another study, 20 patients with recurrent MS were treated rituximab 10 mg once daily in a single infusion for 6 to 8 weeks.13,14 After discontinuing rituximab, the frequency of relapse was significantly decreased during the follow-up period. One previous trial had also demonstrated significantly decreased mortality in women of Order canadian adderall a mean age 73 years who developed relapsing-remitting MS within the first 5 years of treatment.15 A Phase 1, open-label, multicenter randomized trial involving 20 patients showed that treatment with rituximab (25 mg) significantly reduced the annualized relapse rate compared with placebo for a follow-up period of 1 to 2 years.1,2 One study evaluated rituximab in a single-center, multicenter study.17 second study included an 18-month follow-up.18 The final phase 2, double-blind, randomized, placebo control trial involved 18 patients and showed statistically significant improvement in the overall disease activity index in patients treated with rituximab (15 mg) compared those treated with placebo.19 Rituximab had also recently been studied prospectively in a small group of participants who were using a new injection technique.20 No other safety issue was found in this study. addition, rituximab has been tested for a specific immunopathologic disorder; however, the results of a placebo-controlled trial showed no difference in disease activity index for individuals with type 1 diabetes in comparison to the general population.21 A recent randomized, double-blind controlled trial of 18 patients found a significant decrease in the rate of gadolinium-enhancing lesions after treatment with rituximab in patients MS who were on chronic Provigil 200 mg white pill steroid therapy.22 Two patients died during the trial; 2 of these died at the end of study and 1 died due to a cardiac arrest. One patient receiving adjunctive rituximab died of heart failure during the study (see Warnings, Contraindications). Other side effects have occurred with intravenous rituximab therapy in the past but may not occur with oral drug applications for multiple sclerosis. No significant safety issues have been reported.23-25 Rituximab is generally safe and well tolerated.

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